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Congenital malformations arise by reason of embryonic aberration of the uro-rectal septum and pose an enormous challenge for patients and their families. Because continence is already affected at birth, lifelong physical and mental health outcomes are frequently affected by these malformations.

Malformations of the uro-rectal septum include anorectal malformations (ARM) and the exstrophy-epispadias-complex (EEC). They are rare in their occurrence (1:2500 live births) but concern approximately in Germany 280 newborns every year.

The Network for Congenital Uro-REctal malformations (CURE-Net) is a federal program for the research of these rare diseases funded by the German BMBF (Bundesministerium für Bildung und Forschung = Federal Ministry of Education and Research). The aim is to use modern basic genetic and molecular biological research to evaluate the postoperative treatment outcome and different aftercare procedures by multicenter, clinical and psychosocial research via standardized examination procedures prospectively and by a cross-sectional study. Each concerned person and each physician who is in contact with these patients is encouraged to participate.

Network for systematic care of molecular reasons, clinical and psychosocial effects of Congenital Uro-REctal malformations