Welcome to CURE-Net.de

Congenital malformations arise by reason of embryonic aberration of the uro-rectal septum and pose an enormous challenge for patients and their families. Because continence is already affected at birth, lifelong physical and mental health outcomes are frequently affected by these malformations.

Malformations of the uro-rectal septum include anorectal malformations (ARM) and the exstrophy-epispadias-complex (EEC). Their overall birth prevalence has been estimated to be 1:2500 live births, leading to approximately 280 affected newborns in Germany every year.

The Network for Congenital Uro-REctal malformations (CURE-Net) is a federal program for the research of these rare diseases funded by the German BMBF (Bundesministerium für Bildung und Forschung = Federal Ministry of Education and Research) from 2009-2012. The aim is to use modern genetic and molecular biological research to understand the causes of uro-rectal malformations and to evaluate the postoperative treatment outcome and different aftercare procedures by multicenter, clinical and psychosocial research via standardized examination procedures prospectively and by a cross-sectional study. Since 2013 the register is funded by the DFG (Deutsche Forschungsgemeinschaft).
Each concerned person and each physician who is in contact with these patients is encouraged to participate.


Network for Congenital Uro-REctal malformations (CURE-Net)
Systematc investigation of the molecular causes, clinical implications and psychosocial outcome of congenital uro-rectal malformations





News

More then 55 hospitals have ordered case report forms for newborn.

Already 579 patients participate with medical information and from 1068 families DNA was taken. We embrace the popularity, participate as well in our network!